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(2023) with snRNA-seq from normal, pathologic aging, and AD brains identified both increase of reactive genes and a marked decrease in homeostatic genes in protoplasmic astrocytes, correlated to amyloid pathology and loss of normal function

These effects can enhance neuronal function, promote neuroplasticity, and potentially protect against neurodegeneration (Solayman et al

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Acetylation spatial regulation An alternative strategy for controlling enzyme selectivity and activity is through spatial confinement, which enables acetylation to occur preferentially on proteins within specific compartments such as the nucleus, cytoplasm, mitochondria, and endoplasmic reticulum